La documentación científica que respalda y confirma la eficacia de la Hipertermia Médica y Oncológica es abundante y acontinuación se alista algunas de las referencias:

 1. Kampinga HH, Konings AWT: Inhibition of repair of X-ray induced DNA damage by heat: the role of hyperthermic inhibition of DNA polymerase activity. Rad Res, 112: 86-98, 1987.
 2. Kampinga HH, Dynlacht JR, Dikomey E: Mechanism of radiosensitization (43 °C) as derived from studies with DNA repair defective mutant cell lines. Int J Hyperthermia, 20: 131-139, 2004.
 3. Kampinga HH: Cell biological effects of hyperthermia alone or combined with radiation or drugs: A short introduction to newcomers in the field. Int J Hyperthermia, 22: 191-196, 2006.
 4. Borys N: Phase I/II study evaluating the maximum tolerated dose, pharmacokinetics, safety, and efficacy of approved hyperthermia and lyso-thermosensitive liposomal doxorubicin in patients with breast cancer recurrence at the chest wall. ASCO abstracts book, 2010.
 5. Vaupel P, Otte J, Manz R: Changes in tumor oxygenation after localized microwave heating. Prog Clin Biol Res, 107: 65-74, 1982.
 6. Bicher HI, Mitagvaria NP, Bruley DF: Changes in tumor tissue oxygenation during microwave hyperthermia: clinical relevance. Adv Exp Med Biol, 180: 901-905, 1984.
 7. Wahl ML, Bobyock SB, Leeper DB, Owen CS: Effects of 42 degrees C hyperthermia on intracellular pH in ovarian carcinoma cells during acute or chronic exposure to low extracellular pH. Int J Radiat Oncol Biol Phys, 39: 205-212, 1997.
 8. Nakano H, Kurihara K, Okamoto M, Toné S, Shinohara K: Heat-induced apoptosis and p53 in cultured mammalian cells. Int J Radiat Oncol Biol Phys, 71: 519-529, 1997.
 9. Coss RA, Sedar AW, Sistrun SS, Storck CW, Wang PH, Wachsberger PR: Hsp27 protects the cytoskeleton and nucleus from the effects of 42 degrees C at pH 6.7 in CHO cells adapted to growth at pH 6.7. Int J Hyperthermia, 18: 216-232, 2002.
10. Dayanc BE, Beachy SH, Ostberg JR, Repasky EA: Dissecting the role of hyperthermia in natural killer cell mediated anti-tumor responses. Int J Hyperthermia, 24: 41-56, 2008.
11. Hetzel FW, Mattiello J: Interactions of hyperthermia with other modalities. In: Medical physics monograph n° 16. Biological, physical and clinical aspects of hyperthermia. Paliwal BR, Hetzel FW and Dewhirst MW (Eds), pp 30-56, Am Inst Phys, 1987.
12. Manning MR, Cetas TC, Miller RC, Oleson JR, Connor WG, Gerner EW: Clinical hyperthermia: results of a phase I trial employing hyperthermia alone or in combination with external beam or interstitial radiotherapy. Cancer, 49: 205-216, 1982.
13. Dunlop PRC, Hand JW, Dickinson RJ, Field SB: An assessment of local hyperthermia in clinical practise. Int J Hyperthermia, 2: 39-50, 1986.
14. Gabriele P, Orecchia R, Ragona R, Tseroni V, Sannazzari GL: Hyperthermia alone in the treatment of recurrence of malignant tumors. Cancer, 66: 2191-2195, 1990.
15. Valdagni R: International Consensus Meeting on Hyperthermia: Final report. Int J Hyperthermia, 6: 839-877, 1990.
16. Shrivastava P, Luk K, Oleson J, Dewhirst M, Pajak T, Paliwal B, Perez C, Sapareto S, Saylor T, Steeves R: Hyperthermia quality assurance guidelines. Int J Radiat Oncol Biol Phys, 16: 571-587, 1989.
17. Emami B, Stauffer P, Dewhirst MW, Prionas S, Ryan T, Corry P, Herman T, Kapp DS, Myerson RJ, Samulski T, Sapareto S, Sapozink M, Shrivastava P, Waterman F: RTOG quality assurance guidelines for interstitial hyperthermia. Int J Radiat Oncol Biol Phys, 20: 1117-1124, 1991.
18. Sapozink MD, Corry PM, Kapp DS, Myerson RJ, Dewhirst MW, Emami B, Herman T, Prionas S, Ryan T, Samulski T, Sapareto S, Sapozink M, Shrivastava P, Waterman F: RTOG quality assurance guidelines for clinical trials using hyperthermia for deep-seated malignancy. Int J Radiat Oncol Biol Phys, 20: 1109-1115, 1991.
19. Waterman FM, Dewhirst MW, Fessenden P, Samulski TV, Stauffer P, Emami B, Corry P, Prionas SD, Sapozink M, Herman T, Kapp DS, Myerson RJ, Ryan T, Sapareto SA, Shrivastava P: RTOG quality assurance guidelines for clinical trials using hyperthermia administered by ultrasound. Int J Radiat Oncol Biol Phys, 20: 1099-1107, 1991.
20. Kikuchi M, Amemiya Y, Egawa S, Onoyama Y, Kato H, Kanai H, Saito Y, Tsukiyama I, Hiraoka M, Mizushina S, Yamashita T, Nikawa Y, Matsuda J, Miyakawa M: Guide to the use of hyperthermia equipment. 2. Microwave heating. The Japanese Society of Hyperthermic Oncology. Int J Hyperthermia, 9: 341-360, 1993.
21. van der Zee J, Vujaskovic Z, Kondo M, Sugahara T: The Kadota Fund International Forum 2004-clinical group consensus. Int J Hyperthermia, 24: 111-122, 2008.
22. Overgaard J: The current and potential role of hyperthermia in radiotherapy. Int J Radiat Oncol Biol Phys, 16: 535-549, 1989.
23. Valdagni R, Amichetti M: Report of long-term follow-up in a randomized trial comparing radiation therapy and radiation therapy plus hyperthermia to metastatic lymph nodes in stage IV head and neck patients. Int J Radiat Oncol Biol Phys, 28: 163-169, 1994.
24. Overgaard J, Gonzalez Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Mella O, Bentzen SM: Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology. Int J Hyperthermia, 12: 3-20, 1996.
25. Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, van der Zee J, van Putten WL, van Rhoon GC, van Dijk JD, González González D, Liu FF, Goodman P, Sherar M: Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. Int J Radiat Oncol Biol Phys, 35: 731-744, 1996.
26. Wang J, Li D, Chen N: Intracavitary microwave hyperthermia combined with external irradiation in the treatment of esophageal cancer. Zhonghua Zhong Liu Za Zhi, 18: 51-54, 1996.
27. Issels RD, Lindner LH, Wust P, Hohenberger P, Jauch K, Daugaard S, Mansmann U, Hiddemann W, Lay J, Verwei J: Regional hyperthermia improves response and survival when combined with systemic chemotherapy in the management of locally advanced, high grade soft tissue sarcomas of the extremities, the body wall and the abdomen: A phase III randomised prospective study. J Clin Oncol, 25: 18S (June 20 Suppl): 10009, 2007.
28. Prosnitz LR, Maguire P, Anderson JM, Scully SP, Harrelson JM, Jones EL, Dewhirst M, Samulski TV, Powers BE, Rosner GL, Dodge RK, Layfield L, Clough R, Brizel DM: The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy. Int J Radiat Oncol Biol Phys, 45: 941-949, 1999.
29. van der Zee J, Gonzáles Gonzáles D, van Rhoon GC, van Dijk JDP, van Putten WLJ, Hart AAM: Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomized multicentre trial. Dutch Deep Hyperthermia Group. Lancet, 355: 1119-1125, 2000.
30. Berdov BA, Menteshashvili GZ: Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. Int J Hyperthermia, 6: 881-890, 1990.
31. Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma. The Cochrane Collaboration, John Wiley & Sons, Ltd. 2010.
32. The Cochrane Collaboration: Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. John Wiley & Sons, Ltd., 2009.
33. Sneed PK, Stauffer PR, McDermott MW, Diederich CJ, Lamborn KR, Prados MD, Chang S, Weaver KA, Spry L, Malek MK, Lamb SA, Voss B, Davis RL, Wara WM, Larson DA, Phillips TL, Gutin PH: Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiforme. Int J Radiat Oncol Biol Phys, 40: 287-295, 1998.
34. Jones EL, Oleson JR, Prosnitz LR, Samulski TV, Vujaskovich Z, Yu D, Sanders LL, Dewhirst MW: Randomized trial of hyperthermia for superficial tumors. J Clin Oncol, 23: 3079-3085, 2005.
35. van der Zee J, Treurniet-Donker AD, The SK, Helle PA, Seldenrath JJ, Meerwaldt JH, Wijnmaalen AJ, van den Berg AP, van Rhoon GC, Broekmeyer-Reurink MP, Reinhold HS: Low dose reirradiation in combination with hyperthermia: a palliative treatment for patients with breast cancer recurring in a previously irradiated areas. Int J Radiat Oncol Biol Phys, 15 (6): 1407-1413, 1988.
36. Gabbani M, Giudici S, Dall’Oglio S, Romano M, Franchi M, Maluta S: Clinical impact of adding hyperthermia in patients affected by locally advanced cervical cancer treated with chemo-radiotherapy: the experience of Verona multidisciplinary group. 10th International Congress on Hyperthermic Oncology, Munich, 2008.
37. Romano M, Maluta S, Cordiano C, Delaini GG, Genna M, Oliani C, Capelli P, Tomezzoli A, Manfrini C, Porcaro AB, Gabbani M, Chierego G: Pre-operative radio-chemotherapy plus regional hyperthermia in the treatment of advanced rectal cancer: experience with radiation dose escalation. Int J Radiat Oncol Biol Phys, 57: S386-387, 2003.
38. Maluta S, Romano M, Dall'Oglio S, Genna M, Oliani C, Pioli F, Gabbani M, Marciai N, Palazzi M: Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum. Int J Hyperthermia, 26: 108-117, 2010.
39. Palazzi M, Dall’Oglio S, Romano M, Maluta S: Is deep hyperthermia added to chemo-radiotherapy useful in the treatment of locally advanced anal cancer? Verona mono-institutional experience (2000-2006). Tumori, 7: S151, 2008.
40. Maluta S, Dall’Oglio S, Romano M, Marciai N, Pioli F, Giri MG, Benecchi PL, Comunale L, Porcaro AB: Conformational radiotherapy plus local hyperthermia in patients affected by locally advanced high risk prostate cancer: preliminary results of a prospective phase II study. Int J Hyperthermia, 23: 451-456, 2007.
41. Romano M, Palazzi M, Maluta S, Porcaro A: Radiothérapie conformationelle avec modulation d’intensité, hyperthermie profonde régionale et suppression androgénique totale chez des patients atteints d’une tumeur prostatique à haut risque, opérée ou non. Résultats préliminaires chez 20 patients. Cancer Radiothérapie, 13: 687, 2009.
42. Abstract book of ESHO 2010, Rotterdam, May 20-22, 2010.
43. Franckena M, Stalpers LJ, Koper PC, Wiggenraad RG, Hoogenraad WJ, van Dijk JD, Wárlám-Rhodenhuis CC, Jobsen JJ, van Rohon GC, van der Zee J: Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregional advanced cervix cancer: un update of the Dutch Deep Hyperthermia Trial. Int J Radiat Biol Phys, 15: 1176-1182, 2008.
44. Franckena M, Lutgens LC, Koper PC, Kleinen CE, van der Steen-Banasik EM, Jobsen JJ, Leer JW, Creutzberg CL, Dielwart MF, van Norden Y, Canters RA, van Rhoon GC, van der Zee J: Radiotherapy and hyperthermia for treatment of primary locally advanced cervix cancer: results in 378 patients. Int J Radiat Oncol Biol Phys, 73: 242-250, 2009.